Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | KDM6B | O15054 | 1/20 | 0.60 |
| ▸ | KDM4A | O75164 | 1/20 | 0.60 |
| ▸ | KDM5C | P41229 | 1/20 | 0.60 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.60 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.52 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL453628 | 0.87 | KDM4E (0.68) | KDM4EKDM6BKDM4AKDM5CKDM4D | |
| SCHEMBL3798020 | 0.86 | KDM4E (0.45) | KDM4EKDM6BKDM4AKDM5CKDM4D | |
| SCHEMBL3800594 | 0.85 | KDM4E (0.54) | KDM4EKDM6BKDM4AKDM5CKDM4D | |
| SCHEMBL3800591 | 0.80 | KDM4E (0.60) | KDM4EKDM6BKDM4AKDM5CKDM4D | |
| SCHEMBL2383057 | 0.79 | TDP1 (0.41) | KDM4EKDM6BKDM4AKDM5CKDM4D | |
| SCHEMBL2381185 | 0.79 | POLB (0.47) | ALDH1A1HPGDTDP1POLBSMN1; SMN2 | |
| SCHEMBL2385151 | 0.78 | NPC1 (0.53) | KDM4EALDH1A1CXCR2HPGDMAPT | |
| SCHEMBL1742362 | 0.78 | AURKA (0.56) | KDM4EKDM6BKDM4AKDM5CKDM4D | |
| SCHEMBL28603982 | 0.76 | KDM4E (0.62) | KDM4EKDM6BKDM4AKDM5CKDM4D | |
| SCHEMBL5053292 | 0.76 | KDM4E (0.59) | KDM4EKDM6BKDM4AKDM5CKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816393-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2010-10-19 | — | — | US | disclosed |
| US-7816393-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2010-10-19 | — | — | US | disclosed |
| US-7816393-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2010-10-19 | — | — | US | disclosed |
| US-20090291991-A1 | ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE | CELGENE | 2009-11-26 | — | — | US | disclosed |
| US-20090291991-A1 | ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE | CELGENE | 2009-11-26 | — | — | US | disclosed |
| US-20090291991-A1 | ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE | CELGENE | 2009-11-26 | — | — | US | disclosed |
| US-7569597-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569597-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569597-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2009-08-04 | — | — | US | disclosed |
| US-7405237-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2008-07-29 | — | — | US | disclosed |
| US-7405237-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2008-07-29 | — | — | US | disclosed |
| US-7405237-B2 | Isoindoline compounds and methods of their use | CELGENE CORPORATION (US) | 2008-07-29 | — | — | US | disclosed |
| US-20080145336-A1 | Isoindoline compounds and methods of their use | CELGENE CORPORATION | 2008-06-19 | — | — | US | disclosed |
| US-20080145336-A1 | Isoindoline compounds and methods of their use | CELGENE CORPORATION | 2008-06-19 | — | — | US | disclosed |
| US-20080145336-A1 | Isoindoline compounds and methods of their use | CELGENE CORPORATION | 2008-06-19 | — | — | US | disclosed |
| EP-1781610-A2 | ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE | CELGENE CORPORATION (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015060-A2 | ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE | CELGENE CORPORATION (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060025457-A1 | Isoindoline compounds and methods of their use | AMGEN INC. | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080145336-A1 | Isoindoline compounds and methods of their use | PDE4A, PDE4B, PDE4C | KDM4E 1911/4885KDM6B 1901/4885KDM4A 1440/4885 |
| US-20090291991-A1 | ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE | PDE4A, PDE4B, PDE4C | KDM4E 1911/4885KDM6B 1901/4885KDM4A 1440/4885 |
| US-20060025457-A1 | Isoindoline compounds and methods of their use | PDE4A, PDE4B, PDE4C | KDM4E 1911/4885KDM6B 1901/4885KDM4A 1440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.