Diflucortolone

Diflucortolone

SCHEMBL3795

C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]2(C)[C@H]1C(=O)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 8/20 1.00
NR1I2 O75469 3/20 1.00
HTR2B P41595 1/20 1.00
NR3C1 P04150 8/20 0.71
HIF1A Q16665 7/20 0.71
AR P10275 7/20 0.71
SMN1; SMN2 Q16637 3/20 0.71
LMNA P02545 3/20 0.71
ABCB11 O95342 2/20 0.71
CHRM1 P11229 1/20 0.71
CYP3A4 P08684 7/20 0.62
ADORA3 P0DMS8 2/20 0.62
MAPT P10636 2/20 0.62
ALDH1A1 P00352 2/20 0.62
RAB9A P51151 1/20 0.62
MEN1 O00255 1/20 0.57
ALOX15 P16050 1/20 0.57
KMT2A Q03164 1/20 0.57
HSD17B10 Q99714 1/20 0.56
TDP1 Q9NUW8 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diflucortolone SCHEMBL3796 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL11338795 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL5484149 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL3794 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL11856229 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL11855200 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL10052991 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL22040571 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL22039899 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A
Diflucortolone SCHEMBL5484155 1.00 PGR (1.00) PGRNR1I2HTR2BNR3C1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7836 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4683679-A1 METHOD FOR DIAGNOSING AND TREATING NIS-EXPRESSING CARCINOMAS AND METASTASES NUSKE, Andreas (DE) 2026-01-28 EP claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
US-20250213544-A1 ALK5 INHIBITORS AS SKELETAL MUSCLE HYPERTROPHY INDUCERS CYTOO (FR) 2025-07-03 US claimed
US-20250205227-A1 METHODS FOR ADMINISTERING CORTICOSTEROIDS SPARROW PHARMACEUTICALS, INC. 2025-06-26 US claimed
US-12303498-B2 ALK5 inhibitors as skeletal muscle hypertrophy inducers CYTOO (FR) 2025-05-20 US claimed
US-12296043-B2 Liquisoft capsules PATHEON SOFTGELS INC. (US) 2025-05-13 US claimed
US-20250144021-A1 GEL FORMULATIONS FOR LOCAL DRUG RELEASE TECHNICAL UNIVERSITY OF DENMARK (DK) 2025-05-08 US claimed
WO-2025076059-A1 ROCAGLATE DERIVATIVES AND USES THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2025-04-10 WO claimed
EP-3943073-B1 BIODEGRADABLE POLYMER MICROPARTICLE CONTAINING STEROID-BASED DRUG AND PREPARATION METHOD THEREFOR REGENBIOTECH INC (KR) 2025-03-26 EP claimed
EP-4510999-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS Bristol-Myers Squibb Company (US) 2025-02-26 EP claimed
WO-1996012817-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed
US-5407663-A Swishing solution in mouth, expectorating EISEN DRORE (US) 1995-04-18 US claimed
US-5387583-A Advances protective regulation of immune system without giving rise to side effects LORIA, ROGER M. 1995-02-07 US claimed
WO-1994023722-A1 HYDROCORTISONE BUFFERING ACTIVITY LORIA ROGER M (US) 1994-10-27 WO claimed
US-5310545-A Method of treatment using mouthwashes containing steroids and antifungal agents and compositions of matter EISEN DRORE 1994-05-10 US claimed
EP-0173478-B1 Treatment of skin disorders SCOTIA HOLDINGS PLC (GB) 1994-02-02 EP claimed
EP-0496520-A1 Novel bone acting agents MERCK & CO. INC. (US) 1992-07-29 EP claimed
EP-0173478-A1 Treatment of skin disorders SCOTIA HOLDINGS PLC (GB) 1986-03-05 EP claimed
EP-0068553-B1 TOPICAL ANTIMICROBIAL ANTI-INFLAMMATORY COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 1985-11-21 EP claimed