SCHEMBL37951

SCHEMBL37951

O=c1[nH]c2ccccc2[nH]1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.67
GRIN2D O15399 2/20 0.67
GRIN3B O60391 2/20 0.67
GRIN1 Q05586 2/20 0.67
GRIN2A Q12879 2/20 0.67
GRIN2B Q13224 2/20 0.67
GRIN2C Q14957 2/20 0.67
GRIN3A Q8TCU5 2/20 0.67
CA12 O43570 2/20 0.64
PARP1 P09874 2/20 0.64
CA9 Q16790 2/20 0.64
PDE3B Q13370 2/20 0.62
PDE3A Q14432 2/20 0.62
ALDH1A1 P00352 6/20 0.50
HSD17B10 Q99714 4/20 0.50
GAA P10253 3/20 0.50
HPGD P15428 2/20 0.50
LMNA P02545 2/20 0.50
MAPT P10636 2/20 0.50
CYP3A4 P08684 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29367508 1.00 KDM4E (0.67) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL4558727 1.00 KDM4E (0.67) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
Hydrochloric Acid SCHEMBL4647780 0.97 KDM4E (0.63) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
Hydrochloric Acid SCHEMBL30275219 0.97 KDM4E (0.63) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
Hydrochloric Acid SCHEMBL30832797 0.97 KDM4E (0.63) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL14290240 0.84 PDE3B (0.54) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL28765354 0.83 KDM4E (0.48) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL30230748 0.81 KDM4E (0.52) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
Piperidine SCHEMBL8059402 0.81 KDM4E (0.47) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL239920 0.80 KDM4E (1.00) KDM4EGRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9258 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4746923-A2 DELIVERY SYSTEM COMPRISING LIPID OR POLYMERIC NANOPARTICLES COMPRISING THYROID HORMONES FONDAZIONE RICCARDO TERZI E SILVIO ALBINI (IT) 2026-05-27 EP claimed
US-12637410-B2 Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2026-05-26 US claimed
CN-122028939-A Thyroid hormone delivery system comprising lipid or polymer nanoparticles 里卡尔多·泰尔齐与西尔维奥·阿尔比尼基金会 2026-05-12 CN claimed
EP-4127157-B1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS ENCODIA INC (US) 2026-02-11 EP claimed
EP-3623372-B1 PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS VALO HEALTH INC (US) 2026-02-04 EP claimed
EP-4678634-A1 ANDROGEN RECEPTOR MODULATORS AND USES THEREOF Haihe Biopharma Co., Ltd. (CN) 2026-01-14 EP claimed
US-20250388599-A1 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2025-12-25 US claimed
EP-4634169-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF Pfizer Inc. (US) 2025-10-22 EP claimed
US-20250313535-A1 ALPHA 4 BETA 7 INTEGRIN MODULATORS AND USES THEREOF DICE MOLECULES SV, INC. 2025-10-09 US claimed
US-20250289830-A1 KRAS INHIBITORS ELI LILLY AND COMPANY 2025-09-18 US claimed
EP-0005610-B1 1-(HETEROCYCLYLALKYL)-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONES, THEIR PREPARATION, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS BETA-ADRENERGIC RECEPTOR BLOCKERS JANSSEN PHARMACEUTICA N.V. (BE) 1982-12-15 EP claimed
EP-0014928-B1 PIPERIDINOPROPYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1982-05-05 EP claimed
US-4319046-A Preparation of 1,2 diaminobenzene by high pressure acid hydrolysis of benzemidazolone THE SHERWIN-WILLIAMS COMPANY (US) 1982-03-09 US claimed
US-4288442-A Inhibiting adrenergic β-receptors with piperidinopropyl derivatives BOEHRINGER MANNHEIM GMBH (DE) 1981-09-08 US claimed
EP-0000784-B1 4-HYDROXY-2-BENZIMIDAZOLINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS Roche Diagnostics GmbH (DE) 1981-08-26 EP claimed
US-4283508-A Fragrant prevulcanization inhibitors MONSANTO COMPANY (US) 1981-08-11 US claimed
US-4181802-A ADRENERGIC BLOCKING AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 1980-01-01 US claimed
EP-0005610-A2 1-(Heterocyclylalkyl)-1,3-dihydro-2H-benzimidazol-2-ones, their preparation, their pharmaceutical compositions and their use as beta-adrenergic receptor blockers JANSSEN PHARMACEUTICA N.V. (BE) 1979-11-28 EP claimed
US-4113952-A PROCESS FOR PREPARING 2-BENZIMIDAZOLONES THE SHERWIN-WILLIAMS COMPANY (US) 1978-09-12 US claimed
US-3989707-A NEUROLEPTIC AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 1976-11-02 US claimed