Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.47 |
| ▸ | ILK | Q13418 | 4/20 | 0.47 |
| ▸ | KIT | P10721 | 7/20 | 0.44 |
| ▸ | KDM1A | O60341 | 5/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558198 | 1.00 | EGFR (0.47) | EGFRILKKITKDM1AERBB2 | |
| SCHEMBL2047588 | 0.95 | EGFR (0.51) | EGFRILKKITKDM1AERBB2 | |
| SCHEMBL3344457 | 0.76 | EGFR (0.52) | EGFRILKKITKDM1AERBB2 | |
| SCHEMBL8687858 | 0.72 | KIT (0.50) | EGFRKITGAKRIPK2STK10 | |
| SCHEMBL5359866 | 0.71 | EGFR (0.52) | EGFRILKKITKDM1AERBB2 | |
| SCHEMBL1507551 | 0.70 | ENPP1 (0.64) | EGFRKDM1AGAKFLT1FLT4 | |
| SCHEMBL1507495 | 0.70 | ENPP1 (0.64) | EGFRKDM1AGAKFLT1FLT4 | |
| Hydrochloric Acid SCHEMBL4473967 | 0.70 | EGFR (0.52) | EGFRILKKITKDM1AERBB2 | |
| SCHEMBL180323 | 0.67 | EGFR (0.48) | EGFRILKKITKDM1AERBB2 | |
| SCHEMBL1507587 | 0.67 | EGFR (0.90) | EGFRILKKITKDM1AERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120387-A1 | OLIGOMER-PROTEIN TYROSINE KINASE INHIBITOR CONJUGATES | NEKTAR THERAPEUTICS (US) | 2010-10-21 | — | — | WO | disclosed |