Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.52 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.52 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063576 | 0.84 | MAP2K1 (0.38) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL685422 | 0.82 | MAP2K1 (0.61) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL387871 | 0.81 | MAP2K1 (0.58) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3794912 | 0.80 | MAP2K1 (0.41) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL389984 | 0.78 | MAP2K1 (0.62) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3803379 | 0.77 | MAP2K1 (0.37) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL13063776 | 0.76 | MAP2K1 (0.37) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3784573 | 0.76 | MAP2K1 (0.46) | MAP2K1MAP2K2CA2 | |
| SCHEMBL392369 | 0.75 | MAP2K1 (0.47) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL13063593 | 0.73 | MAP2K1 (0.39) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |