Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 2/20 | 0.43 |
| ▸ | RARG | P13631 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.42 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791967 | 0.80 | RARB (0.44) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL8700087 | 0.78 | BCHE (0.44) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL31714583 | 0.77 | RARB (0.40) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL3797862 | 0.76 | HDAC3 (0.41) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL2242248 | 0.75 | BCHE (0.44) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL16896885 | 0.75 | GRIN2D (0.41) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL29706774 | 0.74 | HDAC3 (0.41) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL17276293 | 0.74 | HDAC3 (0.41) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL1764545 | 0.73 | HDAC3 (0.54) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL17968225 | 0.73 | RXRA (0.49) | RARBRARGHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129467-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129467-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |