Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824789 | 0.89 | SIGMAR1 (0.55) | SIGMAR1OPRK1HDAC1HDAC2 | |
| SCHEMBL10766680 | 0.86 | SIGMAR1 (0.66) | SIGMAR1 | |
| SCHEMBL13584782 | 0.83 | MAPT (0.61) | ADRA1ASLC6A3HDAC1HDAC2 | |
| SCHEMBL10453660 | 0.83 | SIGMAR1 (0.91) | SIGMAR1ADRB2ADORA3CHRM1ADRA2B | |
| SCHEMBL2872694 | 0.82 | SIGMAR1 (0.66) | SIGMAR1ADRA1ASLC6A3HDAC1HDAC2 | |
| SCHEMBL11232716 | 0.82 | MAPT (0.57) | SIGMAR1HDAC1HDAC2 | |
| SCHEMBL19438542 | 0.82 | SIGMAR1 (0.59) | SIGMAR1 | |
| SCHEMBL10436247 | 0.81 | HDAC3 (0.74) | HDAC1HDAC2 | |
| SCHEMBL1285919 | 0.81 | MAPT (0.70) | ADRA1ASLC6A3HDAC1HDAC2 | |
| SCHEMBL20689719 | 0.81 | SIGMAR1 (0.91) | SIGMAR1ADRB2ADORA3CHRM1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408450-A1 | A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION | Bristol-Myers Squibb Company (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010107435-A1 | A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-09-23 | — | — | WO | disclosed |