Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9694043 | 0.77 | HSD17B10 (0.52) | APAF1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL29209041 | 0.71 | NPSR1 (0.54) | ALDH1A1TSHRALOX15CREBBPHTT | |
| SCHEMBL12930508 | 0.70 | HTT (0.57) | ALDH1A1POLBTSHRALOX15CREBBP | |
| SCHEMBL15224943 | 0.69 | RPS6KB1 (0.73) | ALDH1A1POLBTSHRHTTLMNA | |
| SCHEMBL5114577 | 0.67 | PTGDR2 (0.64) | — | |
| SCHEMBL18258627 | 0.66 | USP5 (0.66) | APAF1POLBTSHRHTTMEN1 | |
| SCHEMBL30874960 | 0.66 | USP5 (0.66) | APAF1POLBTSHRHTTMEN1 | |
| SCHEMBL1147353 | 0.66 | USP5 (0.66) | APAF1POLBTSHRHTTMEN1 | |
| SCHEMBL28923753 | 0.66 | APAF1 (0.56) | APAF1ALDH1A1POLBTSHRHTT | |
| SCHEMBL8932209 | 0.66 | MEN1 (0.42) | ALDH1A1POLBTSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |