Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 1.00 |
| ▸ | TP53 | P04637 | 6/20 | 1.00 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.86 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.86 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.86 |
| ▸ | NPC1 | O15118 | 8/20 | 0.81 |
| ▸ | RAB9A | P51151 | 8/20 | 0.81 |
| ▸ | MAPT | P10636 | 5/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.81 |
| ▸ | HPGD | P15428 | 2/20 | 0.81 |
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.67 |
| ▸ | RELA | Q04206 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463534 | 0.93 | SMN1; SMN2 (0.93) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL1422890 | 0.93 | CHRNB2 (1.00) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL5959951 | 0.91 | SMN1; SMN2 (0.84) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL1423193 | 0.88 | CHRNB2 (0.83) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL14327841 | 0.87 | SMN1; SMN2 (0.88) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL1423487 | 0.87 | SMN1; SMN2 (0.77) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL8051460 | 0.87 | SMN1; SMN2 (0.77) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL12171589 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL3685718 | 0.84 | CHRNB2 (0.83) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL30843830 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138600-A2 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PAIN | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |