Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795546 | 0.79 | POLB (0.58) | ACHEMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL11900459 | 0.78 | KMT2A (0.37) | MAPTPOLBL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL2473191 | 0.76 | CCNA2 (0.38) | ACHEMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL2471811 | 0.72 | AURKA (0.43) | ACHEMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL19139654 | 0.72 | POLB (0.59) | ACHEMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL11901071 | 0.70 | CCNA2 (0.40) | MAPTPOLBALDH1A1KDM4EHPGD | |
| SCHEMBL2470457 | 0.70 | OPRM1 (0.39) | ACHEMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL3796773 | 0.70 | CNR2 (0.30) | — | |
| SCHEMBL2474886 | 0.69 | OPRM1 (0.36) | ACHEMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL12499362 | 0.68 | BRD4 (0.43) | MAPTPOLBTDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010117425-A1 | CERTAIN SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | BIOGEN IDEC MA INC. (US) | 2010-10-14 | — | — | WO | disclosed |