Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.75 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
| ▸ | GABRE | P78334 | 2/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL599032 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL16570726 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL599031 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL2586572 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL5494142 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL6744292 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL4412378 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL28182547 | 0.98 | SLC7A5 (0.71) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL11018927 | 0.95 | SLC7A5 (0.68) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL10705523 | 0.95 | SLC7A5 (0.68) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210054033-A1 | METHODS AND COMPOSITIONS FOR USE OF RECOMBINANT BACTERIAL EFFECTOR PROTEINS AS ANTI-INFLAMMATORY AGENTS | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY | 2021-02-25 | — | — | US | disclosed |
| WO-2019147988-A1 | METHODS AND COMPOSITIONS FOR USE OF RECOMBINANT BACTERIAL EFFECTOR PROTEINS AS ANTI-INFLAMMATORY AGENTS | INNATE BIOLOGICS LLC (US) | 2019-08-01 | — | — | WO | disclosed |
| US-20130115230-A1 | DELIVERY PROTEINS | AUGMENTA BIOLOGICALS, LLC (US) | 2013-05-09 | — | — | US | disclosed |
| US-20130071413-A1 | TARGETED IMMUNE CONJUGATES | AUGMENTA BIOLOGICALS, LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20100003266-A1 | TARGETED IMMUNE CONJUGATES | AUGMENTA BIOLOGICALS, LLC | 2010-01-07 | — | — | US | disclosed |