Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.75 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
| ▸ | GABRE | P78334 | 2/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL599032 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL16570726 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL3798706 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL2586572 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL5494142 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL6744292 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL4412378 | 1.00 | SLC7A5 (0.75) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL28182547 | 0.98 | SLC7A5 (0.71) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL11018927 | 0.95 | SLC7A5 (0.68) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Valine SCHEMBL10705523 | 0.95 | SLC7A5 (0.68) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120123097-A1 | RICIN A CHAIN MUTANTS LACKING ENZYMATIC ACTIVITY AS VACCINES TO PROTECT AGAINST AEROSOLIZED RICIN | VITETTA ELLEN S (US) | 2012-05-17 | — | — | US | claimed |
| US-8114611-B2 | Affinity chromatography matrices and methods of making and using the same | MILLIPORE CORPORATION (US) | 2012-02-14 | — | — | US | claimed |
| US-20110105730-A1 | AFFINITY CHROMATOGRAPHY MATRICES AND METHODS OF MAKING AND USING THE SAME | MILLIPORE CORPORATION (US) | 2011-05-05 | — | — | US | claimed |
| US-20100063261-A1 | Affinity chromatography matrices and methods of making and using the same | MILLIPORE CORPORATION (US) | 2010-03-11 | — | — | US | claimed |
| EP-1974215-A2 | AFFINITY CHROMATOGRAPHY MATRICES AND METHODS OF MAKING AND USING THE SAME | MILLIPORE CORPORATION (US) | 2008-10-01 | — | — | EP | claimed |
| US-20070207500-A1 | Affinity chromatography matrices and methods of making and using the same | MILLIPORE CORPORATION (US) | 2007-09-06 | — | — | US | claimed |
| WO-2007081851-A2 | AFFINITY CHROMATOGRAPHY MATRICES AND METHODS OF MAKING AND USING THE SAME | MILLIPORE CORPORATION (US) | 2007-07-19 | — | — | WO | claimed |
| US-5545621-A | Glutathione S-transferase-activated compounds | TERRAPIN TECHNOLOGIES, INC. (US) | 1996-08-13 | — | — | US | claimed |
| CN-116103217-A | Pseudomonas fragi vgr gene knockout strain and construction and application thereof | 集美大学 | 2023-05-12 | — | — | CN | disclosed |
| US-11224647-B2 | Safe potent single platform vaccine against Tier 1 select agents and other pathogens | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-01-18 | — | — | US | disclosed |
| US-10837027-B2 | Further improved AAV vectors produced in insect cells | UNIQURE IP B.V. (NL) | 2020-11-17 | — | — | US | disclosed |
| US-20190322702-A1 | Tricalcium Phosphate Binding Peptides And Uses Thereof | ALVAREZ, LUIS | 2019-10-24 | — | — | US | disclosed |
| US-20190240310-A1 | SAFE POTENT SINGLE PLATFORM VACCINE AGAINST TIER 1 SELECT AGENTS AND OTHER PATHOGENS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-08-08 | — | — | US | disclosed |
| US-10329327-B2 | Tricalcium phosphate binding peptides and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-06-25 | — | — | US | disclosed |
| US-5196321-A | Gene expression; splitting with protease | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1993-03-23 | — | — | US | disclosed |
| US-5132213-A | Peptide fusion for genetic engineering and protein synthesis | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1992-07-21 | — | — | US | disclosed |
| US-5093242-A | Ubiquitin-protein fusions, stability | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0408661-A1 | METHODS OF GENERATING DESIRED AMINO-TERMINAL RESIDUES IN PROTEINS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1991-01-23 | — | — | EP | disclosed |
| WO-1989009829-A2 | METHODS OF GENERATING DESIRED AMINO-TERMINAL RESIDUES IN PROTEINS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1989-10-19 | — | — | WO | disclosed |
| EP-0324789-A1 | METHODS OF REGULATING METABOLIC STABILITY OF PROTEINS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1989-07-26 | — | — | EP | disclosed |