Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.44 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755199 | 0.77 | PIK3CA (0.60) | SMG1JAK2CAMK2DIKBKBCHUK | |
| SCHEMBL14423349 | 0.70 | SMG1 (0.48) | SMG1JAK2CLK1DYRK1ACLK4 | |
| SCHEMBL14423356 | 0.69 | JAK2 (0.53) | JAK2CLK1DYRK1ACLK4DYRK1B | |
| SCHEMBL3516373 | 0.69 | IKBKB (0.48) | SMG1JAK2CLK1DYRK1ACLK4 | |
| SCHEMBL3758662 | 0.69 | PIK3CA (0.47) | SMG1JAK2GPR142CDK1CDK2 | |
| SCHEMBL24258525 | 0.68 | CREBBP (0.62) | GPR142 | |
| SCHEMBL4389138 | 0.68 | JAK2 (0.69) | SMG1JAK2CLK1DYRK1ACLK4 | |
| SCHEMBL3517086 | 0.68 | IKBKB (0.52) | SMG1JAK2CLK1DYRK1ACLK4 | |
| SCHEMBL14423383 | 0.68 | SMG1 (0.53) | SMG1JAK2ABL1EGFRJAK3 | |
| SCHEMBL1593016 | 0.67 | PRKCD (0.79) | JAK2CAMK2DABL1EGFRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118208-A1 | BENZOXAZEPIN-4- (5H) -YL DERIVATIVES AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |