Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657516 | 0.77 | CREBBP (1.00) | CREBBP | |
| SCHEMBL21780433 | 0.75 | GPR142 (0.48) | PIK3CACA12CA9GPR142 | |
| SCHEMBL3791990 | 0.73 | PIK3CA (0.46) | CREBBPPIK3CAGPR142HDAC2 | |
| SCHEMBL3793868 | 0.71 | HPGD (0.47) | PIK3CAMAPT | |
| SCHEMBL7236157 | 0.69 | ITGB2 (0.40) | — | |
| SCHEMBL3747407 | 0.69 | PIK3CA (0.66) | CREBBPPIK3CAPRKDC | |
| SCHEMBL3798993 | 0.68 | SMG1 (0.52) | GPR142 | |
| SCHEMBL7084756 | 0.67 | RAB9A (0.64) | CREBBPNPC1MAPTCA12CA1 | |
| SCHEMBL5850255 | 0.67 | NPC1 (0.79) | NPC1CA12CA1CA2CA9 | |
| SCHEMBL24222564 | 0.65 | ABCB1 (0.53) | CREBBPNPC1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |