Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 6/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 8/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.43 |
| ▸ | LYN | P07948 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3008793 | 0.77 | GLA (0.47) | JAK2JAK1TYK2JAK3PRKAA1 | |
| SCHEMBL29205591 | 0.72 | CSF1R (0.51) | JAK2JAK1TYK2JAK3PRKAA1 | |
| SCHEMBL3418416 | 0.72 | APEX1 (0.47) | JAK2JAK1TYK2JAK3PRKAA1 | |
| SCHEMBL1898934 | 0.69 | JAK2 (0.48) | JAK2JAK1TYK2JAK3PRKAA1 | |
| SCHEMBL3029525 | 0.68 | BRD4 (0.41) | JAK2JAK1TYK2JAK3PRKAA1 | |
| SCHEMBL3015334 | 0.68 | LRRK2 (0.44) | JAK2JAK1TYK2JAK3PRKAA1 | |
| SCHEMBL15830210 | 0.68 | GAA (0.44) | MAPK1BRD4 | |
| SCHEMBL410049 | 0.68 | FYN (0.46) | JAK2JAK1TYK2JAK3PRKAA1 | |
| SCHEMBL13085560 | 0.68 | NR3C1 (0.61) | NR3C1PGRNR3C2ARBCHE | |
| SCHEMBL565447 | 0.67 | MAPK1 (0.46) | JAK2JAK1TYK2JAK3PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178870-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025478-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |