Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PARL | Q9H300 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539575 | 0.80 | TSHR (0.48) | SMN1; SMN2TSHRALDH1A1MAPTHTR6 | |
| SCHEMBL31184336 | 0.80 | TSHR (0.48) | SMN1; SMN2TSHRALDH1A1MAPTLMNA | |
| SCHEMBL9539580 | 0.80 | TSHR (0.48) | SMN1; SMN2TSHRALDH1A1MAPTLMNA | |
| SCHEMBL19810089 | 0.80 | TSHR (0.48) | SMN1; SMN2TSHRALDH1A1MAPTHTR6 | |
| SCHEMBL4436494 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRALDH1A1MAPTHTR6 | |
| SCHEMBL27830939 | 0.78 | TSHR (0.46) | SMN1; SMN2TSHRALDH1A1MAPTLMNA | |
| SCHEMBL27259817 | 0.78 | TSHR (0.46) | SMN1; SMN2TSHRALDH1A1MAPTLMNA | |
| SCHEMBL5455252 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRALDH1A1MAPTLMNA | |
| SCHEMBL31215190 | 0.77 | BCAT1 (0.46) | SMN1; SMN2TSHRALDH1A1MAPTLMNA | |
| SCHEMBL21847739 | 0.77 | TDP1 (0.46) | SMN1; SMN2TSHRALDH1A1MAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |