Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.52 |
| ▸ | GRK2 | P25098 | 2/20 | 0.52 |
| ▸ | GRK5 | P34947 | 2/20 | 0.52 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.39 |
| ▸ | FLT4 | P35916 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | NPM1 | P06748 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749350 | 0.92 | IGF1R (0.50) | IGF1RGRK2GRK5CAMK2DMAPK8 | |
| SCHEMBL3803128 | 0.90 | IGF1R (0.64) | IGF1RGRK2GRK5CAMK2DPARP1 | |
| SCHEMBL3804163 | 0.89 | IGF1R (0.54) | IGF1RGRK2GRK5CAMK2DMAPK8 | |
| SCHEMBL3257447 | 0.86 | IGF1R (0.63) | IGF1RGRK2GRK5CAMK2DPARP1 | |
| SCHEMBL3265807 | 0.84 | IGF1R (0.51) | IGF1RGRK2GRK5CAMK2DPARP1 | |
| SCHEMBL3761408 | 0.82 | IGF1R (0.66) | IGF1RGRK2GRK5CAMK2DPARP1 | |
| SCHEMBL3798693 | 0.81 | IGF1R (0.50) | IGF1RGRK2GRK5CAMK2DMAPK8 | |
| SCHEMBL3267799 | 0.81 | IGF1R (0.45) | IGF1RGRK2GRK5CAMK2DALK | |
| SCHEMBL3686711 | 0.80 | IGF1R (0.50) | IGF1RGRK2GRK5CAMK2DMAPK8 | |
| SCHEMBL12429577 | 0.79 | IGF1R (0.81) | IGF1RGRK2GRK5MAPK8GRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |