SCHEMBL379949

SCHEMBL379949

NCc1cc(Cl)ccn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29700591 1.00
Hydrochloric Acid SCHEMBL16400760 0.98 LOXL2 (0.45)
Hydrochloric Acid SCHEMBL23088354 0.98 LOXL2 (0.45)
SCHEMBL11378229 0.83 HRH1 (0.50)
Hydrochloric Acid SCHEMBL14157230 0.81 HRH1 (0.48)
SCHEMBL11274198 0.79 FERMT2 (0.49)
SCHEMBL29774155 0.79
SCHEMBL509733 0.79
SCHEMBL721684 0.77
SCHEMBL29705223 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3515892-B1 COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC (US) 2026-04-15 EP disclosed
US-20260092045-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2026-04-02 US disclosed
US-12581252-B2 Substituted pyrrolo[3,4-b]pyridines as PI3K-α inhibitors RELAY THERAPEUTICS, INC. (US) 2026-03-17 US disclosed
US-12558341-B2 Oral complement factor D inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2026-02-24 US disclosed
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 EP disclosed
US-20260028333-A1 NEW COMPOUNDS VICORE PHARMA AB (SE) 2026-01-29 US disclosed
EP-4630410-A1 POLQ INHIBITORS Astrazeneca AB (SE) 2025-10-15 EP disclosed
US-12435072-B2 Compounds VICORE PHARMA AB (SE) 2025-10-07 US disclosed
US-12414954-B2 POLQ inhibitors ASTRAZENECA AB (SE) 2025-09-16 US disclosed
US-20250195530-A1 POLQ INHIBITORS ASTRAZENECA AB (SE) 2025-06-19 US disclosed
EP-0256990-A1 Pyridinio compounds CIBA-GEIGY AG (CH) 1988-02-24 EP disclosed
US-4352760-A Organic compounds substituted heptadeca-5,9- and 5,10-dienoic acid THE UPJOHN COMPANY (US) 1982-10-05 US disclosed
US-4349690-A ANTISECRETORY, ANTIULCER AGENTS, ANTICOAGULANTS AND ANTIAGGLOMERANTS THE UPJOHN COMPANY (US) 1982-09-14 US disclosed
US-4301078-A SMOOTH MUSCLE STIMULATORS THE UPJOHN COMPANY (US) 1981-11-17 US disclosed
US-4275213-A Isoxazolyl derivatives of 9α,11α-epoxy imino-9,11,15-trideoxy-PGF-type compounds THE UPJOHN COMPANY (US) 1981-06-23 US disclosed
US-4131738-A 6-Hydroxy-PGE1 compounds THE UPJOHN COMPANY (US) 1978-12-26 US disclosed
US-4112224-A PROSTAGLANDIN THE UPJOHN COMPANY (US) 1978-09-05 US disclosed
US-4109082-A PROSTACYCLIN ANALOGS; SMOOTH MUSCLE STIMULATORS THE UPJOHN COMPANY (US) 1978-08-22 US disclosed
US-4100192-A Inter-phenylene-PG amides THE UPJOHN COMPANY (US) 1978-07-11 US disclosed
US-4097489-A PROSTAGLANDINS THE UPJOHN COMPANY (US) 1978-06-27 US disclosed