Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 4/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.33 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.33 |
| ▸ | STK16 | O75716 | 1/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | YES1 | P07947 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645120 | 0.77 | KIT (0.54) | KITCHEK1NTRK1FYNFGFR1 | |
| SCHEMBL2612701 | 0.77 | NTRK1 (0.55) | KITPLK4CHEK1AURKAEPHB6 | |
| SCHEMBL12955038 | 0.76 | NQO2 (0.43) | PDK2PDK4KITNQO2CDK9 | |
| SCHEMBL645525 | 0.76 | FYN (0.40) | KITAAK1PLK4CHEK1AURKA | |
| SCHEMBL644225 | 0.75 | KIT (0.52) | KITFGFR1 | |
| SCHEMBL10287647 | 0.75 | NTRK1 (0.36) | PDK2PDK4KITGRIN1GRIN2B | |
| SCHEMBL645099 | 0.75 | NTRK1 (0.46) | KITPLK4CHEK1AURKAEPHB6 | |
| SCHEMBL3891706 | 0.75 | CDK9 (0.48) | PDK2PDK4KITPLK4CHEK1 | |
| SCHEMBL13594942 | 0.75 | NTRK1 (0.38) | PDK2PDK4KITGRIN1GRIN2B | |
| SCHEMBL644482 | 0.75 | HPGD (0.45) | KITPLK4CHEK1AURKAEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252291-A1 | PHARMACEUTICAL COMPOSITION | Takeda Pharmaceutical Company Limited (JP) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009107877-A1 | PHARMACEUTICAL COMPOSITION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |
| EP-1931669-A1 | KINASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007044779-A1 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2007-04-19 | — | — | WO | disclosed |