Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 12/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379824 | 0.90 | MAPK13 (0.75) | MAPK13MAPK14RAF1PLA2G7 | |
| SCHEMBL380112 | 0.89 | MAPK13 (0.76) | MAPK13MAPK14RAF1PLA2G7 | |
| SCHEMBL379882 | 0.88 | MAPK13 (0.78) | MAPK13MAPK14RAF1PLA2G7MAPK11 | |
| SCHEMBL380253 | 0.85 | MAPK13 (0.74) | MAPK13MAPK14RAF1PLA2G7 | |
| SCHEMBL379821 | 0.85 | MAPK13 (0.74) | MAPK13MAPK14RAF1 | |
| SCHEMBL380034 | 0.83 | MAPK13 (1.00) | MAPK13MAPK14RAF1 | |
| SCHEMBL380661 | 0.83 | MAPK13 (0.73) | MAPK13MAPK14RAF1ABL1 | |
| SCHEMBL379967 | 0.81 | MAPK13 (0.51) | MAPK13MAPK14RAF1ABL1 | |
| SCHEMBL379819 | 0.80 | MAPK13 (0.67) | MAPK13MAPK14RAF1 | |
| SCHEMBL379548 | 0.80 | MAPK13 (0.67) | MAPK13MAPK14RAF1PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |