Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 12/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379661 | 0.82 | MAPK13 (0.76) | MAPK13RAF1MAPK14 | |
| SCHEMBL379963 | 0.81 | MAPK13 (0.71) | MAPK13RAF1MAPK14ABL1 | |
| SCHEMBL8226965 | 0.70 | MAPK14 (0.53) | MAPK14ABL1MAPT | |
| SCHEMBL379824 | 0.70 | MAPK13 (0.75) | MAPK13RAF1MAPK14 | |
| SCHEMBL380112 | 0.69 | MAPK13 (0.76) | MAPK13RAF1MAPK14 | |
| SCHEMBL17232701 | 0.69 | BRD4 (0.41) | MAPK13MAPK14RIPK2KMT2A | |
| SCHEMBL29854461 | 0.69 | MAPK14 (0.51) | MAPK14ABL1MAPT | |
| SCHEMBL379882 | 0.68 | MAPK13 (0.78) | MAPK13RAF1MAPK14RIPK2 | |
| SCHEMBL3277411 | 0.68 | MAPK13 (0.47) | MAPK13RAF1MAPK14KMT2A | |
| SCHEMBL12607518 | 0.67 | MAPK14 (0.50) | MAPK14ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |