Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12681500 | 0.81 | CYP1A2 (0.50) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL10068105 | 0.79 | MAPT (0.47) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL18179779 | 0.78 | MAPT (0.33) | ALDH1A1HPGDGAAMAPTKDM4E | |
| SCHEMBL8408406 | 0.77 | LMNA (0.47) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL17910956 | 0.77 | LMNA (0.43) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL3986078 | 0.77 | LMNA (0.43) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL1457714 | 0.77 | HTT (0.51) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL14339317 | 0.76 | BPTF (0.43) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL23573767 | 0.76 | PLAU (0.38) | HPGDMEN1KMT2AMAPTKDM4E | |
| SCHEMBL5234818 | 0.74 | TSHR (0.52) | LMNAHTTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |