Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 13/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800406 | 0.91 | MAPKAPK5 (0.46) | MAPKAPK5EGFR | |
| SCHEMBL3801156 | 0.90 | MAPKAPK5 (0.58) | MAPKAPK5AURKA | |
| SCHEMBL1477651 | 0.87 | MAPKAPK5 (0.57) | MAPKAPK5FGFR1PKMYT1INSRIGF1R | |
| SCHEMBL1476709 | 0.82 | MAPKAPK5 (0.58) | MAPKAPK5AURKA | |
| SCHEMBL3794145 | 0.82 | MAPKAPK5 (0.48) | MAPKAPK5EGFR | |
| SCHEMBL14207160 | 0.82 | MAPKAPK5 (0.64) | MAPKAPK5ABL1NTRK1YES1KDR | |
| SCHEMBL2218510 | 0.78 | MAPKAPK5 (0.47) | MAPKAPK5FGFR1PKMYT1INSRIGF1R | |
| SCHEMBL12443678 | 0.78 | MAPKAPK5 (0.47) | MAPKAPK5FGFR1PKMYT1INSRIGF1R | |
| SCHEMBL3801487 | 0.76 | MAPKAPK5 (0.61) | MAPKAPK5AURKA | |
| SCHEMBL2217622 | 0.76 | MAPKAPK5 (0.64) | MAPKAPK5ABL1NTRK1YES1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |