Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 15/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3805490 | 0.92 | MAPKAPK5 (0.53) | MAPKAPK5 | |
| SCHEMBL3798752 | 0.92 | MAPKAPK5 (0.61) | MAPKAPK5 | |
| SCHEMBL3798405 | 0.91 | MAPKAPK5 (0.50) | MAPKAPK5NPC1RAB9ABTK | |
| SCHEMBL3795246 | 0.90 | MAPKAPK5 (0.51) | MAPKAPK5 | |
| SCHEMBL3802993 | 0.88 | MAPKAPK5 (0.48) | MAPKAPK5BTK | |
| SCHEMBL3801248 | 0.88 | MAPKAPK5 (0.47) | MAPKAPK5 | |
| SCHEMBL3801252 | 0.88 | MAPKAPK5 (0.47) | MAPKAPK5 | |
| SCHEMBL1476125 | 0.87 | MAPKAPK5 (0.75) | MAPKAPK5FYNMAPK8MAPK9MAPK10 | |
| SCHEMBL3803503 | 0.85 | MAPKAPK5 (0.62) | MAPKAPK5FYNMAPTBTKMAPK8 | |
| SCHEMBL3803496 | 0.85 | MAPKAPK5 (0.60) | MAPKAPK5NPC1POLBMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |