Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 1/20 | 0.58 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.58 |
| ▸ | PI4KA | P42356 | 14/20 | 0.57 |
| ▸ | PI4KB | Q9UBF8 | 14/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.56 |
| ▸ | PIP5K1C | O60331 | 5/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 2/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532470 | 0.81 | PIK3CA (0.82) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL29646253 | 0.81 | PIK3CA (0.82) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL19031537 | 0.79 | ALKBH5 (0.62) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL2770393 | 0.79 | CHEK1 (0.52) | QPCTQPCTLPI4KAPI4KBPIK3CA | |
| SCHEMBL3803308 | 0.78 | PIK3CA (0.51) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL24305690 | 0.76 | MAP4K1 (0.63) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL25303323 | 0.75 | PI4KA (0.72) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL16296381 | 0.75 | PIK3CA (0.77) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL1601334 | 0.74 | QPCT (1.00) | QPCTQPCTLGSK3BROCK2PIM1 | |
| SCHEMBL8773471 | 0.73 | PIK3CA (1.00) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |