Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 7/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076235 | 0.82 | PTGES (0.49) | PTGESJAK2KDM4ENPSR1PTGS1 | |
| SCHEMBL3794463 | 0.80 | PTGES (0.67) | PTGESSCN2AJAK2HPGDS | |
| SCHEMBL3795117 | 0.78 | PTGES (0.54) | PTGESJAK2HPGDSNPY5RKDM4E | |
| SCHEMBL3791357 | 0.77 | PTGES (0.56) | PTGESSCN2AJAK2HPGDSNPY5R | |
| SCHEMBL3797909 | 0.77 | PTGES (0.51) | PTGESJAK2HPGDS | |
| SCHEMBL3790651 | 0.77 | PTGES (0.51) | PTGESJAK2HPGDSNPY5RNPSR1 | |
| SCHEMBL3793877 | 0.76 | PTGES (0.55) | PTGESSCN2AJAK2HPGDSKDM4E | |
| SCHEMBL3791993 | 0.76 | PTGES (0.50) | PTGESJAK2HPGDSNPY5R | |
| SCHEMBL3790517 | 0.75 | PTGES (0.54) | PTGESSCN2AJAK2HPGDSKDM4E | |
| SCHEMBL3792008 | 0.75 | PTGES (0.62) | PTGESSCN2AJAK2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |