Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 8/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3792949 | 0.99 | MAPT (0.53) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL3803951 | 0.94 | MAPT (0.47) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL3793464 | 0.93 | MAPT (0.47) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL14086931 | 0.91 | MAPT (0.54) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL3801074 | 0.88 | MAPT (0.46) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL3803929 | 0.88 | MAPT (0.43) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL3802381 | 0.88 | MAPT (0.45) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL3801076 | 0.87 | MAPT (0.45) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL5335832 | 0.86 | MAPT (0.46) | MAPTKDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL5150469 | 0.84 | MAPT (0.75) | MAPTKDM4EALDH1A1POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714137-B2 | 2,2-Dichloro-N-[2-[3-(2-chloro-6-fluorophenyl)-5-isoxazolyl]-(4-pyridyl)]Acetamide; Hepatitis C virus | RIGEL PHARMACEUTICALS, INC. (US) | 2010-05-11 | — | — | US | disclosed |
| US-7498353-B2 | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-03-03 | — | — | US | disclosed |
| US-7498353-B2 | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-03-03 | — | — | US | disclosed |
| US-7410979-B2 | Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections | RIGEL PHARMACEUTICALS, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7410979-B2 | Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections | RIGEL PHARMACEUTICALS, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-20080171871-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | US | disclosed |
| US-20080171871-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | US | disclosed |
| EP-1699446-B1 | COMPOSITIONS AND METHODS FOR TREATING HEPATITIS C VIRUS (HCV) INFECTION | RIGEL PHARMACEUTICALS INC (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7332602-B2 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-7332602-B2 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070155966-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | RIGEL PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
| US-20070155966-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | RIGEL PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
| WO-2007027230-A2 | HETEROCYCLIC ANTI-VIRAL COMPOUNDS COMPRISING METABOLIZABLE MOIETIES AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| US-7157473-B2 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2007-01-02 | — | — | US | disclosed |
| WO-2005049065-A2 | SYNERGISTIC COMBINATIONS OF DIHALOACETAMIDE WITH INTERFERON OR RIBAVIRIN FOR TREATMENT HCV INFECTIONS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-06-02 | — | — | WO | disclosed |
| US-20040127497-A1 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | MIDCAP FINANCIAL TRUST | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127497-A1 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | HAVCR2, HCCS, NQO1 | MAPT 4676/4885KDM4E 2996/4885ALDH1A1 367/4885 |
| US-20070155966-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | HAVCR2, HCCS, NQO1 | MAPT 4671/4885KDM4E 3087/4885ALDH1A1 395/4885 |
| US-20080171871-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | HAVCR2, HCCS, NQO1 | MAPT 4676/4885KDM4E 2996/4885ALDH1A1 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.