Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.58 |
| ▸ | KDR | P35968 | 8/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.57 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.57 |
| ▸ | STK3 | Q13188 | 3/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | GAK | O14976 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.57 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801013 | 1.00 | AURKA (0.66) | AURKAFGFR1KDRPDGFRBEGFR | |
| SCHEMBL145151 | 0.90 | FGFR1 (0.73) | AURKAFGFR1KDRPDGFRBEGFR | |
| SCHEMBL3794357 | 0.88 | SRC (0.60) | AURKAFGFR1KDRPDGFRBEGFR | |
| SCHEMBL3794353 | 0.88 | SRC (0.60) | AURKAFGFR1KDRPDGFRBEGFR | |
| SCHEMBL3802793 | 0.86 | KDR (0.53) | AURKAFGFR1KDRPDGFRBEGFR | |
| SCHEMBL3802797 | 0.86 | KDR (0.53) | AURKAFGFR1KDRPDGFRBEGFR | |
| SCHEMBL144252 | 0.85 | KDR (0.68) | FGFR1KDRPDGFRBEGFRAURKB | |
| SCHEMBL145476 | 0.83 | MET (0.67) | FGFR1KDRPDGFRBEGFRAURKB | |
| SCHEMBL144892 | 0.83 | KDR (0.61) | AURKAFGFR1KDRPDGFRBEGFR | |
| SCHEMBL144378 | 0.82 | KDR (0.66) | AURKAFGFR1KDRPDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897602-B2 | Indolinone compounds as kinase inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2011-03-01 | — | — | US | claimed |
| US-20100179146-A1 | Indolinone Compounds as Kinase Inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2010-07-15 | — | — | US | claimed |
| US-7897602-B2 | Indolinone compounds as kinase inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2011-03-01 | — | — | US | disclosed |
| US-7897602-B2 | Indolinone compounds as kinase inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2011-03-01 | — | — | US | disclosed |
| US-20100179146-A1 | Indolinone Compounds as Kinase Inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2010-07-15 | — | — | US | disclosed |
| US-20100179146-A1 | Indolinone Compounds as Kinase Inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179146-A1 | Indolinone Compounds as Kinase Inhibitors | CDK2, MAP3K19, MAP3K20 | AURKA 96/4885FGFR1 757/4885KDR 853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.