Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802995 | 0.91 | MAPKAPK5 (0.48) | MAPKAPK5CDK4CCND1 | |
| SCHEMBL2220499 | 0.89 | MAPKAPK5 (0.40) | MAPKAPK5HRH3CCNT1CDK4CCND1 | |
| SCHEMBL3804104 | 0.87 | MAPKAPK5 (0.41) | MAPKAPK5HRH3 | |
| SCHEMBL2220062 | 0.80 | MAPKAPK5 (0.49) | MAPKAPK5CDK4CCND1 | |
| SCHEMBL1476477 | 0.80 | MAPKAPK5 (0.49) | MAPKAPK5HRH3 | |
| SCHEMBL1476043 | 0.80 | MAPKAPK5 (0.49) | MAPKAPK5HRH3 | |
| SCHEMBL3795246 | 0.78 | MAPKAPK5 (0.51) | MAPKAPK5CDK4CCND1 | |
| SCHEMBL1476474 | 0.77 | MAPKAPK5 (0.61) | MAPKAPK5HRH3 | |
| SCHEMBL3798405 | 0.76 | MAPKAPK5 (0.50) | MAPKAPK5JAK2JAK1 | |
| SCHEMBL3803732 | 0.76 | MAPKAPK5 (0.38) | MAPKAPK5JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |