Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 11/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801580 | 0.91 | MAPKAPK5 (0.39) | MAPKAPK5CDK4CCND1 | |
| SCHEMBL2220062 | 0.89 | MAPKAPK5 (0.49) | MAPKAPK5CDK4CCND1TGFBR1ACVR1 | |
| SCHEMBL3795246 | 0.87 | MAPKAPK5 (0.51) | MAPKAPK5CDK4CCND1TGFBR1ACVR1 | |
| SCHEMBL3797919 | 0.84 | MAPKAPK5 (0.51) | MAPKAPK5CDK4CCND1TGFBR1ACVR1 | |
| SCHEMBL3794145 | 0.81 | MAPKAPK5 (0.48) | MAPKAPK5CDK4CCND1SYKF12 | |
| SCHEMBL3793107 | 0.81 | MAPKAPK5 (0.48) | MAPKAPK5CDK4CCND1TGFBR1ACVR1 | |
| SCHEMBL3794137 | 0.81 | MAPKAPK5 (0.43) | MAPKAPK5CDK4CCND1ALK | |
| SCHEMBL2220499 | 0.80 | MAPKAPK5 (0.40) | MAPKAPK5CDK4CCND1SYK | |
| SCHEMBL2223283 | 0.79 | MAPKAPK5 (0.53) | MAPKAPK5CDK4CCND1TGFBR1ACVR1 | |
| SCHEMBL1476500 | 0.79 | MAPKAPK5 (0.61) | MAPKAPK5CDK4CCND1TGFBR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |