Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 4/20 | 0.43 |
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | CMA1 | P23946 | 3/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13026960 | 1.00 | HRH2 (0.43) | HRH2HRH1F2PRSS1GPR119 | |
| SCHEMBL2891032 | 0.91 | F2 (0.42) | HRH2HRH1F2PRSS1ITGB3 | |
| SCHEMBL2891030 | 0.91 | F2 (0.42) | HRH2HRH1F2PRSS1ITGB3 | |
| SCHEMBL8056023 | 0.91 | HRH2 (0.44) | HRH2HRH1F2PRSS1GPR119 | |
| SCHEMBL2890622 | 0.91 | GPR119 (0.41) | HRH2HRH1F2PRSS1GPR119 | |
| SCHEMBL2890619 | 0.91 | GPR119 (0.41) | HRH2HRH1F2PRSS1GPR119 | |
| SCHEMBL13026996 | 0.90 | GPR119 (0.48) | F2PRSS1GPR119KCNH2 | |
| SCHEMBL13026931 | 0.90 | GPR119 (0.43) | HRH2HRH1GPR119CMA1KCNH2 | |
| SCHEMBL2897928 | 0.89 | HRH2 (0.44) | HRH2HRH1GPR119ITGB3ITGA2B | |
| SCHEMBL2897930 | 0.89 | HRH2 (0.44) | HRH2HRH1GPR119ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200609-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009034388-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |