Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.64 |
| ▸ | JAK3 | P52333 | 10/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3804243 | 0.82 | JAK2 (0.64) | JAK2JAK3PTK2KCNH2EGLN2 | |
| SCHEMBL3802131 | 0.81 | JAK2 (0.65) | JAK2JAK3PTK2EGLN2JAK1 | |
| SCHEMBL2640413 | 0.78 | JAK2 (1.00) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2641657 | 0.77 | JAK2 (0.69) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL1422983 | 0.76 | JAK2 (0.57) | JAK2JAK3PTK2KCNH2 | |
| SCHEMBL2641633 | 0.75 | JAK2 (0.70) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3215309 | 0.75 | JAK2 (0.83) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL1422847 | 0.73 | NUDT1 (0.61) | JAK2JAK3PTK2KCNH2EGLN2 | |
| SCHEMBL2641510 | 0.72 | JAK3 (0.67) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3798950 | 0.71 | JAK2 (0.67) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633173-B2 | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives | CEPHALON, INC (US) | 2014-01-21 | — | — | US | disclosed |
| US-20130296312-A1 | Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives | CEPHALON, INC. | 2013-11-07 | — | — | US | disclosed |
| US-8501936-B2 | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives | CEPHALON, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-20100311693-A1 | Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives | CEPHALON, INC. (US) | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296312-A1 | Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives | JAK2, JAK1, JAK3 | JAK2 1/4885JAK3 3/4885PTK2 451/4885 |
| US-20100311693-A1 | Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives | CCNA1, CCNY, RB1 | JAK2 31/4885JAK3 175/4885PTK2 1114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.