Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.80 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.79 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1651188 | 0.89 | PIK3CG (0.80) | PIK3CGDYRK1APIK3CACYP3A4NPC1 | |
| SCHEMBL1651874 | 0.89 | PIK3CG (1.00) | PIK3CGDYRK1APIK3CACYP3A4NPC1 | |
| SCHEMBL10170616 | 0.88 | DYRK1A (1.00) | PIK3CGDYRK1APIK3CACYP3A4NPC1 | |
| SCHEMBL3716998 | 0.88 | PIK3CG (0.79) | PIK3CGDYRK1APIK3CACYP3A4NPC1 | |
| SCHEMBL1653742 | 0.88 | PIK3CG (0.78) | PIK3CGDYRK1APIK3CACYP3A4NPC1 | |
| SCHEMBL3877305 | 0.88 | PIK3CG (0.78) | PIK3CGDYRK1APIK3CACYP3A4NPC1 | |
| SCHEMBL1621188 | 0.86 | PIK3CG (0.78) | PIK3CGDYRK1APIK3CACYP3A4 | |
| SCHEMBL20887499 | 0.85 | DYRK1A (0.72) | PIK3CGDYRK1APIK3CACYP3A4NPC1 | |
| SCHEMBL3717675 | 0.85 | PIK3CG (0.71) | PIK3CGDYRK1APIK3CACYP3A4NPC1 | |
| SCHEMBL3712303 | 0.84 | PIK3CG (0.69) | PIK3CGDYRK1APIK3CACYP3A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009133127-A1 | FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS | MERCK SERONO S.A. (CH) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133127-A1 | FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS | MERCK SERONO S.A. (CH) | 2009-11-05 | — | — | WO | disclosed |