SCHEMBL380424

SCHEMBL380424

CNCCCN(C)C(=O)c1ccc(NCCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)cc1F

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.50
CHRM3 P20309 19/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL783823 0.94 CHRM3 (0.51) CHRM2CHRM3
SCHEMBL380442 0.93 CHRM2 (0.51) CHRM2CHRM3
SCHEMBL380962 0.93 SLC2A1 (0.52) CHRM2CHRM3
SCHEMBL380992 0.90 CHRM2 (0.60) CHRM2CHRM3
SCHEMBL381053 0.89 CHRM2 (0.60) CHRM2CHRM3
SCHEMBL380148 0.89 CHRM2 (0.55) CHRM2CHRM3
SCHEMBL380326 0.87 CHRM3 (0.64) CHRM3
SCHEMBL783752 0.86 CHRM3 (0.53) CHRM2CHRM3
SCHEMBL380568 0.86 CHRM3 (0.54) CHRM2CHRM3
SCHEMBL783791 0.86 CHRM2 (0.50) CHRM2CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8476253-B2 Amide derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-07-02 US disclosed
EP-2409977-A1 AMIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2012-01-25 EP disclosed