Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719721 | 0.88 | MET (0.72) | METCYP3A4 | |
| SCHEMBL3729175 | 0.88 | MET (0.71) | METCYP3A4 | |
| SCHEMBL3721442 | 0.87 | MET (0.70) | METCYP3A4NPC1RAB9A | |
| SCHEMBL3723505 | 0.87 | MET (0.70) | METCYP3A4 | |
| SCHEMBL3721438 | 0.87 | MET (0.70) | METCYP3A4 | |
| SCHEMBL3728091 | 0.86 | MET (0.70) | METCYP3A4 | |
| SCHEMBL3725108 | 0.86 | MET (0.70) | METCYP3A4NPC1RAB9A | |
| SCHEMBL3722205 | 0.85 | MET (0.68) | METCYP3A4 | |
| SCHEMBL3725115 | 0.85 | MET (0.72) | METCYP3A4 | |
| SCHEMBL3726531 | 0.85 | MET (0.65) | METCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393790-A1 | DERIVATIVES OF 6-(6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS | SANOFI (FR) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089506-A1 | DERIVATIVES OF 6-(6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2010-08-12 | — | — | WO | disclosed |