Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 18/20 | 0.80 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379880 | 0.96 | MAPK13 (0.84) | MAPK13MAPK14CYP3A4 | |
| SCHEMBL380115 | 0.94 | MAPK13 (0.81) | MAPK13MAPK14CYP3A4 | |
| SCHEMBL379879 | 0.92 | MAPK14 (0.76) | MAPK13MAPK14 | |
| SCHEMBL379890 | 0.90 | MAPK14 (0.80) | MAPK13MAPK14 | |
| SCHEMBL379825 | 0.89 | MAPK13 (1.00) | MAPK13MAPK14 | |
| SCHEMBL379930 | 0.88 | MAPK13 (0.80) | MAPK13MAPK14 | |
| SCHEMBL380485 | 0.87 | MAPK13 (0.84) | MAPK13MAPK14 | |
| SCHEMBL380777 | 0.86 | MAPK14 (0.88) | MAPK13MAPK14CYP3A4 | |
| SCHEMBL3614569 | 0.85 | MAPK13 (0.80) | MAPK13MAPK14 | |
| SCHEMBL380640 | 0.84 | MAPK13 (0.83) | MAPK13MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |