Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 17/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2138351 | 0.86 | CLK1 (0.67) | CLK1DYRK1ADYRK1BCLK2CLK4 | |
| SCHEMBL30805945 | 0.81 | CLK1 (0.57) | CLK1DYRK1ADYRK1BCLK2CLK4 | |
| SCHEMBL15697592 | 0.81 | CLK1 (0.57) | CLK1DYRK1ADYRK1BCLK2CLK4 | |
| SCHEMBL9431275 | 0.79 | DYRK1A (0.51) | CLK1DYRK1ADYRK1BMEN1MAPT | |
| SCHEMBL31108990 | 0.78 | MEN1 (0.64) | CLK1DYRK1ADYRK1BCLK2CLK4 | |
| SCHEMBL3641925 | 0.78 | DYRK1A (0.68) | CLK1DYRK1ADYRK1BMEN1MAPT | |
| SCHEMBL2895953 | 0.78 | MEN1 (0.64) | CLK1DYRK1ADYRK1BCLK2CLK4 | |
| SCHEMBL15697489 | 0.78 | HDAC1 (0.61) | CLK1DYRK1ADYRK1BMEN1MAPT | |
| SCHEMBL10949789 | 0.78 | TBXAS1 (0.48) | CLK1DYRK1ADYRK1BCLK2CLK4 | |
| SCHEMBL100069 | 0.77 | MAPT (0.52) | CLK1DYRK1ADYRK1BMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874295-A4 | BENZOTHIOPHENE DERIVATIVES | MERCK & CO INC (US) | 2009-08-12 | — | — | EP | disclosed |
| EP-1874295-A1 | BENZOTHIOPHENE DERIVATIVES | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006115845-A1 | BENZOTHIOPHENE DERIVATIVES | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | disclosed |