Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 3/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.52 |
| ▸ | BACE1 | P56817 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427076 | 1.00 | GAA (0.54) | GAAMEN1KMT2ABCHEACHE | |
| SCHEMBL3810502 | 1.00 | GAA (0.54) | GAAMEN1KMT2ABCHEACHE | |
| Hydrochloric Acid SCHEMBL4425500 | 0.98 | GAA (0.52) | GAAMEN1KMT2ABCHEACHE | |
| Hydrochloric Acid SCHEMBL4432892 | 0.98 | GAA (0.52) | GAAMEN1KMT2ABCHEACHE | |
| Hydrochloric Acid SCHEMBL4427412 | 0.98 | GAA (0.52) | GAAMEN1KMT2ABCHEACHE | |
| SCHEMBL25373516 | 0.90 | GAA (0.62) | GAAMEN1KMT2ABCHEACHE | |
| SCHEMBL4848550 | 0.90 | GAA (0.62) | GAAMEN1KMT2ABCHEACHE | |
| SCHEMBL1021686 | 0.89 | ALDH1A1 (0.60) | MEN1KMT2ABCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL4846915 | 0.88 | GAA (0.61) | GAAMEN1KMT2ABCHEACHE | |
| SCHEMBL4845501 | 0.88 | ALDH1A1 (0.61) | GAAMEN1KMT2ABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306141-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | US | disclosed |
| US-7528156-B2 | Compounds | ASTRAZENECA AB (SE) | 2009-05-05 | — | — | US | disclosed |
| US-6911458-B2 | Compounds | ASTRA ZENECA (SE) | 2005-06-28 | — | — | US | disclosed |
| US-20050090494-A1 | Novel compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2005-04-28 | — | — | US | disclosed |
| US-20030162772-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2003-08-28 | — | — | US | disclosed |
| EP-1299357-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001098273-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306141-A1 | Novel Compounds | CHRM2, CHRM1, C1R | GAA 2229/4885MEN1 61/4885KMT2A 1199/4885 |
| US-20050090494-A1 | Novel compounds | CHRM2, CHRM1, C1R | GAA 2229/4885MEN1 61/4885KMT2A 1199/4885 |
| US-20030162772-A1 | Novel compounds | RPS4X, RPS4Y1, MRPS18A | GAA 962/4885MEN1 228/4885KMT2A 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.