SCHEMBL381123

SCHEMBL381123

CC1([N+](=O)[O-])C=CC(C(=O)O)=CC1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.31
HCAR3 P49019 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11749331 0.85 ALDH1A1 (0.33)
SCHEMBL27844559 0.82 MAPK1 (0.37) TDP1
SCHEMBL28256317 0.81 GSK3B (0.37)
SCHEMBL29025596 0.78
SCHEMBL29105242 0.78 MAPT (0.30)
SCHEMBL28176113 0.77
SCHEMBL28602824 0.77
SCHEMBL3100514 0.77
SCHEMBL28987456 0.76
SCHEMBL28740520 0.75 ALDH1A1 (0.32) HCAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3689881-B1 MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B EISAI R&D MAN CO LTD (JP) 2022-01-12 EP disclosed
CN-102439007-A Amide derivatives DAIICHI SANKYO CO LTD 2012-05-02 CN disclosed
EP-2409977-A1 AMIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2012-01-25 EP disclosed