Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29900878 | 0.87 | ULK1 (0.58) | MAPK8MAPK10MAPK9IGF1RALK | |
| SCHEMBL375665 | 0.87 | ULK1 (0.58) | MAPK8MAPK10MAPK9IGF1RALK | |
| SCHEMBL2061282 | 0.86 | ULK1 (0.56) | MAPK8MAPK10MAPK9IGF1RALK | |
| SCHEMBL30421641 | 0.86 | ULK1 (0.56) | MAPK8MAPK10MAPK9IGF1RALK | |
| SCHEMBL13809933 | 0.84 | ALK (0.43) | MAPK8MAPK10MAPK9IGF1RALK | |
| SCHEMBL375921 | 0.84 | MAPK8 (0.49) | MAPK8MAPK10MAPK9IGF1RALK | |
| SCHEMBL31174579 | 0.84 | MAPK8 (0.49) | MAPK8MAPK10MAPK9IGF1RALK | |
| SCHEMBL17194046 | 0.83 | MAPK10 (0.52) | MAPK8MAPK10MAPK9IGF1RALK | |
| SCHEMBL5563903 | 0.81 | CDC7 (0.55) | MAPK8MAPK10MAPK9GSK3BCDC7 | |
| SCHEMBL1204025 | 0.81 | MAPK8 (0.48) | MAPK8MAPK10MAPK9IGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597251-B1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-10 | — | — | EP | disclosed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
| EP-1597251-A2 | PYRIMIDINE COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074244-A2 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010668-A1 | Pyrimidine compounds | TYMS, TYMP, DPYD | MAPK8 3281/4885MAPK10 3487/4885MAPK9 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.