Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MLNR | O43193 | 1/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30222321 | 1.00 | MEN1 (0.59) | MEN1KMT2ALMNAMAPTCYP19A1 | |
| SCHEMBL4229377 | 0.86 | ALDH1A1 (0.55) | MEN1KMT2ALMNAMAPTCYP19A1 | |
| SCHEMBL2028009 | 0.86 | HTT (0.58) | MEN1KMT2ALMNAMAPTCYP19A1 | |
| SCHEMBL4229181 | 0.85 | ALDH1A1 (0.69) | MEN1KMT2ALMNAMAPTCYP19A1 | |
| SCHEMBL4229257 | 0.84 | TTR (0.69) | MEN1KMT2AMAPTHPGDKDM4E | |
| SCHEMBL14861188 | 0.84 | TBXA2R (0.54) | MEN1KMT2ALMNAMAPTCYP19A1 | |
| SCHEMBL124556 | 0.84 | TBXA2R (0.54) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL5553432 | 0.84 | MAPT (0.55) | MEN1KMT2ALMNAMAPTCYP19A1 | |
| SCHEMBL21295542 | 0.84 | MAPT (0.55) | MEN1KMT2ALMNAMAPTCYP19A1 | |
| SCHEMBL30744006 | 0.84 | MAPT (0.55) | MEN1KMT2ALMNAMAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240391931-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS FOR USE AS HER2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2024-11-28 | — | — | US | disclosed |
| CN-117980309-A | Tricyclic fused pyrimidine compounds useful as HER2 inhibitors | 百时美施贵宝公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-110483366-B | Indole compound and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-09-16 | — | — | CN | disclosed |
| EP-3080098-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2017-12-06 | — | — | EP | disclosed |
| EP-3080098-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2017-12-06 | — | — | EP | disclosed |
| US-9802920-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMAN-LA ROCHE INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-9802920-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMAN-LA ROCHE INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-20160304497-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | CHUGAI PHARMACEUTICAL CO. (JP) | 2016-10-20 | — | — | US | disclosed |
| US-20160304497-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | CHUGAI PHARMACEUTICAL CO. (JP) | 2016-10-20 | — | — | US | disclosed |
| EP-3080098-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. Hoffmann-La Roche AG (CH) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015086636-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015086636-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-18 | — | — | WO | disclosed |
| EP-1631292-B1 | 4-ANILINO-QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2009-08-05 | — | — | EP | disclosed |
| US-20070149546-A1 | 4-Anilino-quinazoline derivatives as antiproliferative agents | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | disclosed |
| EP-1631292-A1 | 4-ANILINO-QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | Astra Zeneca AB (SE) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004093880-A1 | 4-ANILINO-QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149546-A1 | 4-Anilino-quinazoline derivatives as antiproliferative agents | ABL1, ERBB2, ERBB4 | MEN1 1383/4885KMT2A 1711/4885LMNA 3225/4885 |
| US-20240391931-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS FOR USE AS HER2 INHIBITORS | ERBB2, ERBB3, EGFR | MEN1 4250/4885KMT2A 2304/4885LMNA 4363/4885 |
| US-20160304497-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | MEN1 3807/4885KMT2A 1959/4885LMNA 4183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.