Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 6/20 | 0.56 |
| ▸ | CTSV | O60911 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3807294 | 0.85 | PIN1 (0.59) | PIN1POLBPLK1PTK2GSK3B | |
| SCHEMBL3809036 | 0.85 | PIN1 (0.52) | PIN1PLK1PTK2GSK3BGSK3A | |
| SCHEMBL3811561 | 0.84 | PIN1 (0.67) | PIN1CTSVCTSLPLK1PTK2 | |
| SCHEMBL3808780 | 0.81 | PLK1 (0.64) | PIN1PLK1PTK2GSK3BGSK3A | |
| SCHEMBL13866473 | 0.81 | PLK1 (0.72) | CTSVCTSLPLK1PTK2GSK3B | |
| SCHEMBL1204172 | 0.81 | PIN1 (0.62) | PIN1PLK1PTK2GSK3BGSK3A | |
| SCHEMBL3814860 | 0.81 | PIN1 (0.62) | PIN1PLK1PTK2GSK3BGSK3A | |
| Hydrochloric Acid SCHEMBL3814314 | 0.80 | PLK1 (0.71) | CTSVCTSLPLK1PTK2GSK3B | |
| SCHEMBL2062751 | 0.79 | PIN1 (0.59) | PIN1PLK1PTK2GSK3BGSK3A | |
| SCHEMBL3812071 | 0.78 | PIN1 (0.51) | PIN1PLK1PTK2GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597251-B1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-10 | — | — | EP | disclosed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
| EP-1597251-A2 | PYRIMIDINE COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074244-A2 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010668-A1 | Pyrimidine compounds | TYMS, TYMP, DPYD | PIN1 1535/4885CTSV 3803/4885CTSL 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.