Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 19/20 | 0.49 |
| ▸ | INSR | P06213 | 9/20 | 0.49 |
| ▸ | TXK | P42681 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812178 | 0.87 | ITK (0.53) | ITKINSRTXKIRAK4 | |
| SCHEMBL3801872 | 0.78 | ITK (0.51) | ITKINSRTXKIRAK4 | |
| SCHEMBL3797852 | 0.78 | ITK (0.50) | ITKINSRTXK | |
| SCHEMBL3801300 | 0.78 | ITK (0.47) | ITKINSRTXK | |
| SCHEMBL13077039 | 0.77 | ITK (0.57) | ITKINSRTXK | |
| SCHEMBL19236089 | 0.76 | ITK (0.53) | ITKINSRTXKIRAK4 | |
| SCHEMBL3800898 | 0.76 | ITK (0.66) | ITKINSRTXK | |
| SCHEMBL3796215 | 0.75 | ITK (0.54) | ITKINSRTXKIRAK4 | |
| SCHEMBL3791176 | 0.72 | ITK (0.47) | ITKINSR | |
| SCHEMBL3798557 | 0.72 | KDM4E (0.52) | ITKINSRIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |