Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 17/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819668 | 0.88 | GRM5 (0.48) | GRM5ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL3811660 | 0.87 | GRM5 (0.45) | GRM5ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL1011304 | 0.85 | GRM5 (0.62) | GRM5ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL3819269 | 0.85 | GRM5 (0.53) | GRM5ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL3820291 | 0.84 | GRM5 (0.52) | GRM5ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL3819323 | 0.80 | GRM5 (0.52) | GRM5ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL1010056 | 0.80 | GRM5 (0.72) | GRM5ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL3815966 | 0.80 | SPR (0.56) | ALDH1A1GAAMAPTHPGDTSHR | |
| SCHEMBL3820115 | 0.80 | GRM5 (0.48) | GRM5ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL3810384 | 0.78 | GRM5 (0.56) | GRM5ALDH1A1GAAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |