Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 10/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2388728 | 0.91 | POLB (0.46) | POLBCAPN1CTSBSTAT3XIAP | |
| SCHEMBL27781840 | 0.91 | POLB (0.46) | POLBCAPN1CTSBSTAT3XIAP | |
| SCHEMBL30906745 | 0.89 | XPNPEP1 (0.51) | POLBCAPN1CTSBSTAT3KMT2A | |
| SCHEMBL11090289 | 0.88 | KMT2A (0.53) | CAPN1CTSBXIAPKMT2A | |
| SCHEMBL3808437 | 0.87 | POLB (0.46) | POLBCAPN1CTSBSTAT3XIAP | |
| SCHEMBL3808351 | 0.86 | STAT3 (0.48) | CAPN1CTSBSTAT3 | |
| SCHEMBL3814324 | 0.86 | POLB (0.48) | POLBCAPN1CTSBSTAT3KMT2A | |
| SCHEMBL3817152 | 0.83 | OPRM1 (0.61) | — | |
| SCHEMBL11661759 | 0.81 | KMT2A (0.64) | POLBKMT2ASMN1; SMN2ITGB1ITGA4 | |
| SCHEMBL3046422 | 0.81 | KMT2A (0.64) | POLBKMT2ASMN1; SMN2ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086993-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | Zedira GmbH (DE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008055488-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2008-05-15 | — | — | WO | claimed |
| EP-2086993-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | Zedira GmbH (DE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008055488-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2008-05-15 | — | — | WO | disclosed |