Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13719449 | 0.90 | MEN1 (0.35) | HTTLMNAMAPK1GRM5MEN1 | |
| SCHEMBL3812059 | 0.90 | HTT (0.40) | HTTLMNAMAPK1GRM5MEN1 | |
| SCHEMBL13720192 | 0.85 | HTT (0.39) | HTTLMNAMAPK1GRM5MEN1 | |
| SCHEMBL1869352 | 0.84 | GRM5 (0.52) | GRM5MEN1KMT2AGAATSHR | |
| SCHEMBL3819401 | 0.83 | KMT2A (0.41) | HTTLMNAMAPK1GRM5MEN1 | |
| SCHEMBL3814000 | 0.82 | GRM5 (0.39) | HTTLMNAMAPK1GRM5MEN1 | |
| SCHEMBL3816485 | 0.82 | NPC1 (0.34) | HTTLMNAMAPK1GRM5RAB9A | |
| SCHEMBL3817616 | 0.82 | HTT (0.40) | HTTLMNAMAPK1GRM5MEN1 | |
| SCHEMBL3815429 | 0.82 | HTT (0.40) | HTTLMNAMAPK1GRM5MEN1 | |
| SCHEMBL3813334 | 0.81 | TRPC3 (0.44) | GRM5RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |