Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 4/20 | 0.33 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812059 | 0.90 | HTT (0.40) | HTTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL13719449 | 0.90 | MEN1 (0.35) | HTTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3813205 | 0.85 | HTT (0.37) | HTTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL8220910 | 0.84 | GRM5 (0.45) | LMNAGRM5POLBALDH1A1GAA | |
| SCHEMBL3818792 | 0.83 | KMT2A (0.39) | HTTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3812712 | 0.83 | KMT2A (0.41) | HTTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3816607 | 0.83 | KMT2A (0.42) | HTTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3814892 | 0.82 | MEN1 (0.38) | HTTMAPK1MEN1KMT2AGRM5 | |
| SCHEMBL3815233 | 0.82 | ALDH1A1 (0.32) | HTTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL8012792 | 0.82 | DRD1 (0.49) | HTTMEN1KMT2AGRM5TRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |