Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 9/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4085846 | 1.00 | MAPK8 (0.56) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL4080526 | 0.96 | MAPK8 (0.52) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL4084849 | 0.87 | CNR2 (0.51) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL3797476 | 0.87 | CNR2 (0.51) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL3799426 | 0.84 | CNR2 (0.40) | MAPK8MAPK9MAPK10CNR2CNR1 | |
| SCHEMBL4086759 | 0.84 | CNR2 (0.40) | MAPK8MAPK9MAPK10CNR2CNR1 | |
| SCHEMBL3806688 | 0.83 | CNR2 (0.60) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL4080886 | 0.83 | CNR2 (0.60) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL3756414 | 0.81 | CNR2 (0.64) | KDM4EALDH1A1HPGDLMNAMAPT | |
| SCHEMBL4095706 | 0.80 | TP53 (0.64) | KDM4EALDH1A1HPGDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176219-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009009550-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2009-01-15 | — | — | WO | disclosed |