Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PEPD | P12955 | 3/20 | 0.57 |
| ▸ | XPNPEP1 | Q9NQW7 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 8/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.46 |
| ▸ | FAP | Q12884 | 5/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 3/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29880455 | 0.86 | PEPD (0.56) | PEPDXPNPEP1DPP4DPP8FAP | |
| SCHEMBL5970696 | 0.83 | ACE (0.57) | PEPDDPP4DPP8FAPDPP9 | |
| SCHEMBL5970700 | 0.83 | ACE (0.57) | PEPDDPP4DPP8FAPDPP9 | |
| SCHEMBL2408415 | 0.83 | OPRM1 (0.48) | DPP4DPP8FAPDPP9DPP7 | |
| SCHEMBL7403908 | 0.81 | DPP4 (0.59) | PEPDXPNPEP1DPP4DPP8DPP9 | |
| SCHEMBL4067266 | 0.81 | DPP4 (0.59) | PEPDXPNPEP1DPP4DPP8DPP9 | |
| SCHEMBL4067269 | 0.81 | DPP4 (0.59) | PEPDXPNPEP1DPP4DPP8DPP9 | |
| SCHEMBL4337499 | 0.81 | DPP4 (0.45) | DPP4DPP8FAPDPP9DPP7 | |
| SCHEMBL4337493 | 0.81 | DPP4 (0.45) | DPP4DPP8FAPDPP9DPP7 | |
| SCHEMBL15528751 | 0.80 | ACE (0.53) | PEPDDPP4DPP8FAPDPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086993-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | Zedira GmbH (DE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008055488-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2008-05-15 | — | — | WO | claimed |
| EP-2086993-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | Zedira GmbH (DE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008055488-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2008-05-15 | — | — | WO | disclosed |