Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 17/20 | 1.00 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188844 | 0.90 | TRPM8 (1.00) | TRPM8TRPV1EPHX2 | |
| SCHEMBL13188131 | 0.90 | TRPM8 (1.00) | TRPM8TRPV1EPHX2 | |
| SCHEMBL13188901 | 0.88 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL13188824 | 0.84 | TRPM8 (0.81) | TRPM8TRPV1EPHX2 | |
| SCHEMBL13189138 | 0.79 | TRPM8 (0.80) | TRPM8TRPV1EPHX2 | |
| SCHEMBL13188827 | 0.78 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL13188834 | 0.76 | TRPM8 (0.74) | TRPM8TRPV1 | |
| SCHEMBL13188815 | 0.76 | TRPM8 (1.00) | TRPM8TRPV1 | |
| SCHEMBL13188132 | 0.76 | TRPM8 (0.79) | TRPM8TRPV1EPHX2 | |
| SCHEMBL13189005 | 0.76 | TRPM8 (0.78) | TRPM8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | disclosed |